Search results for "Cns depressant"

showing 3 items of 3 documents

Comparison of the effects of chloral hydrate and trichlorethanol on the EEG of the isolated perfused rat brain.

1973

An isolated perfused rat brain preparation was used to compare the effects of chloral hydrate and its metabolite trichloroethanol on the EEG. The concentrations of chloral hydrate and trichloroethanol in the perfusion medium ranged from 1.5 to 5.5 mM. 5, 10, 15, and 30 min after the beginning of the perfusions EEG-recordings were taken. The recordings were evaluated both by a descriptive method and by a simple quantitative appraoch, counting the waves with an amplitude greater than 50 microvolts and averaging this value for a period of 1 sec. The following results were obtained: Both drugs exhibited CNS depressant activity. Between 5 and 10 min of perfusion the effect of trichloroethanol wa…

Central Nervous SystemMaleTime FactorsMetaboliteCns depressantPharmacology toxicologyChloral hydrateElectroencephalographyIn Vitro Techniqueschemistry.chemical_compoundmedicineAnimalsChloral HydratePharmacologymedicine.diagnostic_testEthanolChemistryHydrocarbons HalogenatedBrainElectroencephalographyGeneral MedicineRat brainRatsPerfusionAnesthesiaChlorinePerfusionmedicine.drugNaunyn-Schmiedeberg's archives of pharmacology
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Evaluation of the analgesic and CNS actions of different fractions from the methanol extract ofTeucrium flavum L.

1998

Different fractions (F.1, F-3, F-5, F-6, F-7, F-8) of the methanol extract from Teucrium flavum L. have been tested for their central nervous system and analgesic activities at a dose of 200 mg/kg. Fractions F-1, F-3 and F-7 showed CNS depressant activity, while fractions F-5, F-6 and F-8 had a slight CNS stimulant action. Fractions F-5, F-6, F-7 and F-8 were responsible for the analgesic activity of the extract.

PharmacologyTraditional medicinebusiness.industryCns depressantCentral nervous systemAnalgesicBiological activityPharmacognosyTeucrium flavumlaw.inventionchemistry.chemical_compoundmedicine.anatomical_structurechemistrylawmedicineMethanolPhytotherapybusinessPhytotherapy Research
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Zentral dämpfende Wirkstoffe, 7. Mitt. Kernsubstituierte (Diallylamino)-1,3,5-triazine

1988

Aus der Umsetzung von 2,4-Dichlor-6-(diallylamino)-1,3,5-triazin (1) mit langkettigen primaren (2a-b) und cyclischen sekundaren (2c-f) Aminen gehen die kernsubstituierten Chlor-diallylamino-1,3,5-triazine (3a-f) hervor. Ein fur Strukturtyp 3 charakteristischer ms Fragmentierungsweg beinhaltet die Umbildung der Diallylaminogruppe zum Aziridinring. Unter den neu entwickelten Verbindungen findet sich zentral dampfende Wirksamkeit besonders in 3a ausgepragt. Daruber hinaus weist Strukturtyp 3 Antiprotozoen-, anthelminthische und insektenwachstumsregulatorische Wirkung auf. CNS Depressants, VII: (Diallylamino)-1,3,5-triazines Substituted at the Triazine Nucleus The reaction of 2,4-dichloro-6-(di…

chemistry.chemical_compoundchemistryStereochemistryCns depressantDrug DiscoveryPharmaceutical ScienceCns depressantsAziridineMass spectrometricTriazineArchiv der Pharmazie
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